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KMID : 0644120110240040001
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Journal of Oriental Gynecology
2011 Volume.24 No. 4 p.1 ~ p.9
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Inhibitory Effects of Wogonin Mixed with Hydrogel on Osteoclast Differentiation
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Yang Na-Rae
Lee Jin-Moo
Lee Chang-Hoon
Jang Jun-Bock
Lee Kyung-Sub
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Abstract
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Purpose: Wogonin is an active component isolated from scutellariae radix. This study was conducted to evaluate the inhibitory effect of wogonin mixed with hydrogel on osteoclast differentiation.
Methods: It was performed to estimate cytotoxicity of Wogonin alginate hydrogel disk(WHD) in BMMs stimulated with RANKL, M-CSF. ROS synthesis and actin ring formation were analysed to observe the effect of WHD.
Results: WHD has no cytotoxicity at the concentration of 0.1 or lower. 0.1 , 1 WHD restrained the synthesis of ROS and 0.1 , 1 WHD restrained the formation of actin ring.
Conclusions: WHD has the inhibitory effect of osteoclast differentiation and bone resorption. Further studies are needed to treat osteoporosis by herbal medicine.
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KEYWORD
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Scutellariae Radix, Wogonin alginate hydrogel disk, osteoclast, hydrogel, RANK ligand
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